Platelet-Rich Plasma vs Corticosteroid Injections for Knee Osteoarthritis
Comparative Study of Functional Outcome of Intra-articular Injection of Platelet-Rich Plasma versus Corticosteroid in Treatment of Osteoarthritis of Knee.
J Orthop Case Rep . 2025 Apr;15(4):287-292.Forty patients with radiographically confirmed knee osteoarthritis (OA) were randomized to receive intra-articular platelet-rich plasma (PRP) (n=20) or intra-articular (IA) corticosteroid (n=20). The primary outcome of interest was knee pain/function by WOMAC; secondary outcomes included Lequesne index. Outcomes were assessed at baseline, 1, 3, and 6 months. Overall, the results showed statistically significant between-group differences at 1, 3, and 6 months for both WOMAC (p=0.011, 0.026, 0.002) and Lequesne (all p<0.005). By the reported group means (lower scores conventionally better), corticosteroid had lower WOMAC and Lequesne at all follow-ups; however, the authors concluded PRP provided greater improvement in pain, stiffness, and function over the short term. These findings suggest potential benefit of PRP, but interpretation is tempered by apparent inconsistencies between tabulated means and the narrative conclusion.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics