Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2024;12(6):5 Am J Sports Med . 2023 Aug;51(10):2625-2634.What this means for my practice?
Orthopaedic surgeons should consider alternative treatment options for ankle osteoarthritis as PRP injections did not demonstrate a significant improvement in symptoms and function over 52 weeks as compared to placebo. However, it is essential to acknowledge the limitations of the study, including potential variations in PRP composition and the absence of a detailed analysis of the PRP composition.
Study Summary
One hundred patients with ankle osteoarthritis were randomly assigned to receive either intra-articular platelet-rich plasma injections (PRP; n=48) or intra-articular placebo injections (n=52). The primary outcome was the patient-reported American Orthopaedic Foot & Ankle Society (AOFAS) score over 52 weeks. Secondary outcomes included various patient-reported measures assessing pain, function, quality of life, and indirect costs over the same period. The adjusted between-group difference for the patient-reported AOFAS score at 52 weeks favored the placebo group by 2 points (95% CI, 25 to 2; P = .31). With regards to secondary outcomes, there were no statistically significant between-group differences observed as was measured at 52 weeks post procedure. Overall, this indicates that PRP injections did not significantly improve ankle symptoms and function compared to placebo.
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