Platelet-rich fibrin matrix may be detrimental in rotator cuff tendon healing .
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The effect of platelet-rich fibrin matrix on rotator cuff tendon healing: a prospective, randomized clinical study
Am J Sports Med. 2012 Jun;40(6):1234-41. doi: 10.1177/0363546512442924. Epub 2012 Apr 1079 patients undergoing arthroscopic rotator cuff repair were randomized to receive repair with either Platelet Rich Fibrin Matrix (PRFM) or a standard repair to determine if PRFM was able to improve repair integrity or functional outcomes. After a year of follow up, the PRFM did not have an effect on tendon healing, tendon vascularity, manual muscle strength, or clinical ratings. Conversely, PRFM was a predictor of tendon defect at 12 weeks, demonstrated through regression analysis.
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