A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the "Plants for Joints" randomized controlled trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Sixty-six patients with metabolic syndrome-associated osteoarthritis (MSOA) of the hip or knee were randomized to receive either a 16-week multidisciplinary lifestyle program in addition to usual care (n=32) or usual care alone (n=32). The primary outcome was change in the WOMAC total score. Secondary outcomes included WOMAC pain, stiffness, and physical function subscores, PROMIS measures, body weight, fat mass, waist circumference, inflammatory and metabolic markers. Outcomes were assessed at baseline, 8 weeks, and 16 weeks. Overall, the results of the study revealed that the intervention group achieved significantly greater improvements in WOMAC total score, pain, stiffness, and physical function, along with reductions in body weight, fat mass, waist circumference, CRP, HbA1c, fasting glucose, and LDL cholesterol compared with controls. These findings suggest that a multidisciplinary lifestyle program centered on a whole-food plant-based diet can effectively reduce symptoms and improve metabolic health in patients with MSOA.