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Trauma

Pilot Study - Fluid lavage of open wounds: The need for RCT of irrigation approaches

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Pilot Study - Fluid lavage of open wounds: The need for RCT of irrigation approaches .

This report has been verified by one or more authors of the original publication.

Fluid Lavage of Open Wounds (FLOW): A Multicenter, Blinded,Factorial Pilot Trial Comparing Alternative Irrigating Solutions and Pressures in Patients With Open Fractures

J Trauma. 2011 Sep;71(3):596-606.

Contributing Authors

Mohit Bhandari Gordon Guyatt Kyle Jeray Bradley Petrisor Emil Schemitsch Parag Sancheti Jeff Anglen Paul Tornetta Michael Bosse

Exclusive Author Interview

Dr. Brad Petrisor discusses a pilot study examining the fluid lavage of open wounds

111 patients at different centers across the world with open fracture wound were randomized to be treated with either castile soap solution or normal saline and either high- or low-pressure pulsatile lavage. The primary composite outcome of reoperation, measured at 12 months after initial operative procedure, included infection, wound healing problems, and nonunion. Secondary outcomes included the functional outcomes scores. No statistically significant difference was found between treatments because of the low adverse event rate, but data suggests that the low pressure lavage may be beneficial in decreasing the infection risk, this yet remains to be proven in a bigger RCT.

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