60 patients with chronic non-specified low back pain were randomized to either a control group (continued medication treatment) or to participate in biweekly pilates sessions in addition to continued medication treatment. The purpose of this study was to evaluate the impact of pilates as a method of therapeutic exercise on pain, function, and quality of life. Pain, function, quality of life, flexibility, satisfaction with treatment and amount of non-steroidal anti-inflammatory drugs (NSAIDs) ingested during the treatment period were measured at baseline, and 45, 90 and 180 days after baseline. The results of this study suggest that pilates is an effective intervention to reduce pain, improve function, decrease the use of NSAIDs and enhance quality of life in patients with chronic low back pain.