Pharmacokinetics of escalating doses of oral psilocybin .
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Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults
Clin Pharmacokinet. 2017 11-Apr;():. 10.1007/s40262-017-0540-6Twelve participants attended 3 separate dosing session, separated by 4 weeks each, of increasing doses of oral psilocybin (0.3, 0.45, 0.6 mg/kg). Participants had blood drawn and urine samples taken at multiple timepoints following administration of psilocybin in order to determine pharmacokinetics of psilocyn. The elimination half life of psilocyn was 3+/-1.1 hours, while an extended elimination phase in some subjects suggest there may be a hydrolysis of the psilocyn glucuronide metabolite.
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