P300-mediated modulations in self-other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self-other overlap
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):10 Hum Brain Mapp. 2020 23-Feb;():. 10.1002/hbm.25174What this means for my practice?
Psilocybin reduced distinct self- and other-related neural scalp configurations during the P300 timeframe, compared to placebo. These effects were also associated with the intensity of psilocybin-induced feelings of unity and changed meaning of percepts. More specifically, the probability of attributing the 'self' voice to the 'self' source dropped significantly more than the probability of recognizing the 'other' voice as 'other'. There were also significant self/other differences in topographical configurations under the placebo, but not psilocybin. These findings are consistent with previous research on how psilocybin alters the experience of self through ego-dissolution. These findings also provide a neurological basis for self-referential processing. Possible limitations include task disengagement driving the effects of psilocybin on self/other processing, carry-over effects and the efficacy of the double-blind procedures.
Study Summary
Seventeen healthy subjects underwent a double-blind, placebo-controlled, within-subject crossover study to examine the effects of psilocybin on the processing of self-stimuli. Subjects received psilocybin (230 μg/kg) and a placebo dose two weeks apart and underwent a verbal self-monitoring task after administration, while EEG data was collected. Under psilocybin, self-experience interacted with the source of the task (self/other) to affect task accuracy. The late phase of self-stimuli encoding was affected by the removal of the distinct self- and other-related electric field configurations during the P300 timeframe. This effect was driven by current source density changes within the supragenual anterior cingulate and right insular cortex.
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