TRAUMA
Outcome of hemiarthroplasty and total hip replacement for active elderly patients with displaced femoral neck fractures: a meta-analysis of 8 randomized clinical trials
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2014;2(15):22 PLoS One. 2014 May 22;9(5):e98071. doi: 10.1371/journal.pone.0098071.8 randomized controlled trials (n=983) were included in this meta-analysis comparing outcomes between total hip arthroplasty and hemiarthroplasty in elderly patients. Results indicated significantly higher Harris Hip scores and a significantly lower risk of revision in the total hip arthroplasty group when compared to hemiarthroplasty. There was, however, a trend towards a higher rate of dislocation for total hip arthroplasty, although not statistically significant. The most common complication requiring revision surgery was acetabular erosion. As a whole, total hip arthroplasty appeared to be favoured over hemiarthroplasty in this population.
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Were the criteria used for assessing the validity of the included studies reported?
Was the validity of all of the studies referred to in the text assessed with use of appropriate criteria (either in selecting the studies for inclusion or in analyzing the studies that were cited)?
Were the methods used to combine the findings of the relevant studies (to reach a conclusion) reported?
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報告基準評価では、著者が出版物内で試験の方法論的特徴や試験特性を報告する際の透明性を評価します。評価は以下の5つのカテゴリーに分類されます。
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Introduction
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Accessing Data
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Analysing Data
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Results
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Discussion
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
Fragility Indexは、重要な所見の解釈を助けるツールで、結果の強さの尺度を提供します。Fragility Indexは、その所見が有意でなくなるために、二項対立の結果に追加する必要がある連続した事象の数を表します。数値が小さいほど弱い所見を表し、数値が大きいほど強い所見を表します。
なぜ今この研究が必要なのですか？
Fractures of the femoral head are becoming increasingly prevalent with the aging population. Treatment options include internal fixation, hemiarthroplasty, and total hip arthroplasty. The latter two options are preferred over internal fixation, due to the associated risks of nonunion, avascular necrosis, and mechanical failure with fixation. However, the optimal method between the two arthroplasty techniques for elderly individuals remains controversial, emphasizing a need for this meta-analysis.
主な研究課題は何ですか？
How do hemiarthroplasty and total hip arthroplasty compare in elderly patients?
重要な知見は？
- Harris hip scores (HHS) were reported in 5 studies. Pooled results significantly favoured total hip arthroplasty over hemiarthroplasty at 1 year (SMD: -7.11 [95% CI -10.70 to -3.53]; p<0.05) and 2 years postoperatively (SMD:-6.91 [95% CI -12.98 to -0.85]; p<0.05).
- Dislocation rate was measured in 6 studies; 5 studies were pooled (n=691). Results indicated a non-significant trend towards a higher rate for total hip arthroplasty (33/390) compared to hemiarthroplasty (14/421), (RR: 0.46 [95% CI 0.21-1.02]; P = 0.06; I-squared = 14%) with low heterogeneity.
- Revision rates were reported in 5 studies, and pooling demonstrated a higher revision rate for hemiarthroplasty (32/352) compared to total hip arthroplasty (11/321) (RR: 2.58 [95% CI 1.04-6.40]; P=0.04; I-squared = 19%), with low heterogeneity.
- Complications resulting in revision surgery for hemiarthroplasty were most commonly acetabular erosion, followed by periprosthetic fracture, acetabulum osteoarthritis, and deep infection. For total hip arthroplasty, the most common was infection, followed by femoral stem subsidence, acetabulum osteoarthritis and dislocation.
- Heterogeneity in reporting of surgical time, blood loss and transfusion did not allow for pooling.
最も覚えておくべきことは？
Total hip arthroplasty was associated with significantly higher Harris Hip scores and a lower risk for revision, while hemiarthroplasty resulted in a lower dislocation rate. The most common complication for total hip arthroplasty was infection, whereas acetabular erosion was highest in hemiarthroplasty.
それが私の患者ケアにどのように影響するか？
As a whole, the results from this analysis suggest total hip arthroplasty may hold benefits over hemiarthroplasty in elderly patients with a femoral head fracture. Patients treated with total hip arthroplasty appeared to enjoy better hip outcomes and lower revision rates. Trials with longer follow-up and assessment of health-related quality of life outcomes are recommended to add to this body of literature. Addtionally, further research should consider possible methods of reducing dislocation rates for those undergoing total hip arthroplasty.
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