OTA2017: Thromboprophylaxis with nadroparin or fondaparinux versus control after below-knee casting .
Prophylaxis of Venous Thromboembolism in Patients with a Nonsurgical Fracture of the Lower Extremity Immobilized in a Below-Knee Plaster Cast: A Randomized Controlled Trial
467 patients managed with a below-knee plaster cast for a foot or ankle fracture were randomized to either subcutaneous nadroparin 2850IE daily, subcutaneous fondaparinux 2.5mg daily, or no thromboprophylaxis intervention (control). Patients were screened during follow-up for cases of deep vein thrombosis and pulmonary embolism. Results demonstrated significantly lower rates of deep vein thrombosis in both the nadroparin and fondaparinux groups compared to the control group.
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