OTA 2023: Reducing Opioid Use and Pain in Polytrauma Patients with Low-Dose, Short-Term IV Ketorolac .
Low-Dose Short-term Scheduled Ketorolac Reduced Opioid Use and Pain in Orthopaedic Polytrauma Patients: A Randomized Clinical Trial
70 orthopaedic polytrauma patients were randomized to receive 5 days of intravenous low-dose ketorolac (n=35) or a placebo (n=35). The main outcomes of interest included length of stay, opioid consumption, and post-operative pain scores. The ketorolac group did not show any advantage in length of stay outcome compared to placebo, but reported significantly lower opioid consumption and pain scores than the placebo group. The results of this study suggest that administering non-steroidal anti-inflammatory drugs could minimize pain for orthopaedic polytrauma patients. Future studies to assess long-term safety and efficacy are required.
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