OTA 2013: Trend towards reduced rescue medication following surgery with 75mg pregabalin .
A Double-Blind Trial Of Pregabalin As An Adjunct To Post-Operative Pain In Orthopaedic Trauma Patients
81 patients with a trauma related fracture underwent surgery and were administered adjunct pregabalin or a placebo to determine if pregabalin administration was an effective pain management strategy. Patients were randomized into three groups to receive low or high doses of pregabalin (75 or 150 mg) or a placebo twice a day for the duration of hospitalization. The results suggest a trend towards less required rescue medication in patients who were administered 75 mg of pregabalin; however, a post hoc calculation revealed a need for a larger sample size to validate this finding. Higher doses of pregabalin resulted in higher pain at rest and with activity.
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