Osteosarcoma: methotrexate & doxorubicin versus methotrexate, etoposide & ifosfamide .
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SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients
Eur J Cancer. 2007 Mar;43(4):752-61. Epub 2007 Jan 30234 patients with nonmetastatic osteosarcoma were randomized to preoperative chemotherapy of high-dose methotrexate with either doxorubicin or with etoposide and ifosfamide. After a median of 77-month follow-up, patients who had received the etoposide-ifosfamide regimen exhibited a larger percentage of good histologic response. Three- and 5-year overall and event-free survival rates were significantly better in those who had a good histologic response. Furthermore, although the event-free survival was slightly greater in the etoposide-ifosamide group compared to the doxorubicin group, this difference was not found to be statistically significant.
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