Osteoporosis: Zoledronic acid increases bone mineral density and reduces fracture rate .
Efficacy of intravenous zoledronic acid in the prevention and treatment of osteoporosis: A meta-analysis
Asian Pac J Trop Med. 2012 Sep;5(9):743-8. doi: 10.1016/S1995-7645(12)60118-7This meta-analysis included 9 studies comparing zoledronic acid and a placebo in patients with osteoporosis. Results from the analysis indicated that zoledronic acid was effective in increasing bone mineral density and reducing fracture rate. The zoledronic acid group also demonstrated a significantly lower rate of serious adverse events than the control group. According to subgroup analyses, older patients (over 50 years) and those who received the intervention longer (more than 12 months) benefited most from zoledronic acid.
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