Osteogenic protein-1 is safe and effective in the treatment of tibial nonunion .
This report has been verified
by one or more authors of the
original publication.
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions
J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S151-8122 patients with 124 tibial nonunions were treated with intramedullary nailing and randomized to receive a fresh bone autograft or recombinant human osteogenic protein-1 (rhOP-1). Patients were assessed for severity of pain at the fracture site, the ability to walk with full weightbearing, need for surgical re-treatment of the nonunion, radiographic evaluation of healing, and physician satisfaction with the clinical course. Clinical and radiographic judgments of healing were not significantly different between the two groups through 2 years.
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