Nonsurgical treatment is recommended for proximal humeral fractures in elderly patients .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2014;2(1):32 PLoS One. 2013 Sep 16;8(9):e75464Three randomized control trials with a total of 130 patients were pooled in this meta-analysis to compare non-operative treatment methods versus open reduction and internal fixation for proximal humerus fractures in the elderly. No differences were found in Constant Scores, nonunion rate, risk of avascular necrosis of the humeral head or osteoarthritis. The results of this study do not encourage the surgical treatment for older patients with fractures of the proximal humerus.
Were the search methods used to find evidence (original research) on the primary question or questions stated?
Was the search for evidence reasonably comprehensive?
Were the criteria used for deciding which studies to include in the overview reported?
Was the bias in the selection of studies avoided?
Were the criteria used for assessing the validity of the included studies reported?
Was the validity of all of the studies referred to in the text assessed with use of appropriate criteria (either in selecting the studies for inclusion or in analyzing the studies that were cited)?
Were the methods used to combine the findings of the relevant studies (to reach a conclusion) reported?
Were the findings of the relevant studies combined appropriately relative to the primary question that the overview addresses?
Were the conclusions made by the author or authors supported by the data and or analysis reported in the overview?
How would you rate the scientific quality of this evidence?
Sì = 1
Incerto = 0,5
Non rilevante = 0
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La valutazione dei criteri di segnalazione valuta la trasparenza con cui gli autori riportano le caratteristiche metodologiche e sperimentali dello studio all'interno della pubblicazione. La valutazione è suddivisa in cinque categorie che vengono presentate di seguito.
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Introduction
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Accessing Data
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Analysing Data
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Results
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Discussion
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
L'Indice di Fragilità è uno strumento che aiuta l'interpretazione dei risultati significativi, fornendo una misura della forza di un risultato. L'Indice di Fragilità rappresenta il numero di eventi consecutivi che devono essere aggiunti a un risultato dicotomico per rendere il risultato non più significativo. Un numero piccolo rappresenta un risultato più debole, mentre un numero grande rappresenta un risultato più forte.
Perché questo studio era necessario ora?
Six percent of all fractures treated in the emergency department are proximal humeral fractures and the majority can be successfully treated without surgery. These fractures are the most common type of fracture occurring in elderly patients and 13 to 16% are comminuted, displaced and categorized as 3- and 4-part fractures according to the Neer Classification. Controversy lies in the whether comminuted displaced fractures in elderly patients with osteoporosis who experienced low energy trauma should be treated with surgery or not. A select number of randomized control studies compare open reduction and internal fixation to conservative methods and this meta-analysis was brought forward to pool the data from the trials available to re-evaluate the use of both treatments.
Qual era la domanda di ricerca principale?
Are comminuted displaced humeral fractures in elderly patients best treated with open reduction and internal fixation or non-operative treatments?
- All three studies (n=130) examined Constant score and the outcomes were similar between surgical and nonsurgical treatment groups (WMD 20.51, 95% CI: 27.25 to 6.22, P= 0.88, I squared = 0%).
- The 3 studies found nonunion was uncommon in both groups and that the difference between the two was insignificant (RR =0.78; 95% CI: 0.18–3.41, P= 0.74, I squared = 0%).
- In the 3 RCT's examined, no difference was found in the risk of avascular necrosis of humeral head (RR = 0.86; 95% CI: 0.46–1.58, P= 0.62, I squared =0%).
- 2 of the studies (82 patients) reported data on osteoarthritis and neither treatment arm provided additional benefits (RR = 1.34; 95% CI: 0.37–4.82, P= 0.66, I squared =0%).
Che cosa devo ricordare di più?
No benefits were found regarding constant score, nonunion rate, risk of avascular necrosis of the humeral head or osteoarthritis with open reduction and internal fixation over nonsurgical methods. Both nonunion rates and risk of avascular necrosis were low in each group.
Come influenzerà l'assistenza ai miei pazienti?
This meta-analysis of 3 randomized control studies suggests non-operative treatment should be used for 3- and 4-part proximal humeral fractures in elderly patients over open reduction and internal fixation, as there is no additional benefit of the operative treatment. This study was limited by the modest quantity of studies and few clinical outcomes observed.
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