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No significant effect of fibrin sealant on postoperative function following total knee arthroplasty
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ARTHROPLASTY
No significant effect of fibrin sealant on postoperative function following total knee arthroplasty .

The effect of a fibrin sealant on knee function after total knee replacement surgery. Results from the FIRST trial. A multicenter randomized controlled trial

PLoS One. 2018 Jul 25;13(7):e0200804. doi: 10.1371/journal.pone.0200804

498 patients scheduled for total knee arthroplasty were randomized to either intraoperative fibrin sealant application or to no additional fibrin sealant. Patients were assessed for the primary outcome of change in knee extension angle after 2 weeks. Among secondary outcomes included the change in knee flexion angle, length of hospital stay, and incidence of complications. Results demonstrated no significant difference between the fibrin sealant and control group for either improvement in knee extension angle, improvement in knee flexion angle, length of hospital stay, or incidence of complications.

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OrthoEvidence. No significant effect of fibrin sealant on postoperative function following total knee arthroplasty. ACE Report. 2018;7(8):15. Available from: https://myorthoevidence.com/AceReport/Show/no-significant-effect-of-fibrin-sealant-on-postoperative-function-following-total-knee-arthroplasty

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