No significant difference in pain or function after MACI with weight-bearing after 6, 8, or 10 weeks .
This report has been verified
by one or more authors of the
original publication.
Is Delayed Weightbearing After Matrix-Associated Autologous Chondrocyte Implantation in the Knee Associated With Better Outcomes? A Systematic Review of Randomized Controlled Trials
Orthop J Sports Med. 2018 May 9;6(5):2325967118770986Seven randomized controlled trials were included in this systematic review which compared outcomes after matrix-associated autologous chondrocyte implantation (MACI) between groups of patients allocated to weight-bearing by 6 weeks, groups of patients allocated to weight-bearing by 8 weeks, and groups of patients allocated to weight-bearing by 10-11 weeks. Qualitatively, similar changes in pain and functional measures were observed among protocols, and studies demonstrated significant improvement in these measures from preoperatively to final follow-up. There were no differences in failure rate between groups.
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