Autologous Chondrocyte Implantation Versus Microfracture in the Knee: A Meta-analysis and Systematic Review

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

For the past four decades, many different avenues have been explored in efforts to repair and restore damaged cartilage zones in weightbearing zones, none more well-studied than the knee. Autologous Chondrocyte Implantation (ACI), which has gone through multiple "generations" of development, has held promise but produced inconsistent results. Microfracture is the classic surgical option, but is known to produce fibrocartilage which is of lesser quality than articular cartilage. In this study, the authors compared ACI to microfracture in patients with cartilage defects of the knee. They included 12 RCTs with 659 patients, and assessed pain, function, quality of life, and failure. While ACI outperformed microfracture in terms of activities of daily living, quality of life at five years, and pain at two years, the differences were small and inconsistent over time. Overall, there do not appear to be any definitive benefits of ACI over microfracture.