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No effect of GLP-1 receptor agonists on fracture incidence in type 2 diabetes treatment
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No effect of GLP-1 receptor agonists on fracture incidence in type 2 diabetes treatment

Use of glucagon-like peptide-1 receptor agonists and bone fractures: a meta-analysis of randomized clinical trials

J Diabetes. 2014 May;6(3):260-6. doi: 10.1111/1753-0407.12102. Epub 2013 Nov 22
Contributing Authors

G Mabilleau A Mieczkowska D Chappard

Seven randomized controlled trials were included in this meta-analysis investigating the effect of glucagon-like peptide (GLP)-1 receptor agonists on bone fracture incidence in patients with type 2 diabetes mellitus. The purpose was to determine if treatment with GLP-1 receptor agonists led to a significantly lower rate of bone fracture when compared to either placebo or other antidiabetic drugs. Pooled results on fracture incidence demonstrated no significant difference between GLP-1 receptor agonists and comparators.

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OrthoEvidence. No effect of GLP-1 receptor agonists on fracture incidence in type 2 diabetes treatment . ACE Report. 2016;5(12):42. Available from: https://myorthoevidence.com/AceReport/Show/no-effect-of-glp-1-receptor-agonists-on-fracture-incidence-in-type-2-diabetes-treatment

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