No differences in 2- and 5-yr clinical outcome between PRP and HA for knee osteoarthritis .
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Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial
Am J Sports Med. 2019 Feb;47(2):347-354. doi: 10.1177/0363546518814532192 patients with knee osteoarthritis were randomized to three weekly intraarticular injections with either platelet-rich plasma or hyaluronic acid. The focuse of the current study was outcome after 2 and 5 years following treatment. Results for clinical outcome on the International Knee Documentation Committee (IKDC) subjective score, the EuroQoL 5-dimensions (EQ-5D) and the Tegner activity scale demonstrated no significant differences between the PRP group and HA group at 2 or 5 years. Within the first 2 years of treatment, rate of reintervention, including either repeat injection therapy or surgery, was significantly lower in the PRP group compared to the HA group. However, at 5 years, the rate of reintervention did not significantly differ between groups.
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