Injection therapies for plantar fasciopathy ('plantar fasciitis'): a systematic review and network meta-analysis of 22 randomised controlled trials.

22 randomized controlled trials were included in this network meta-analysis, that included over 10 injectable treatments, to evaluate comparative efficacy for the management of plantar faciopathy. The primary outcome of this study was pain relief. At 0-2 month follow-up, micronized dehydrated human amniotic/chorionic membrane was the most likely treatment to be effective for pain relief. At 2-6 months, botulinum toxin A was the treatment most likely to be effective for pain relief, while a treatment most likely to be effective beyond 12 months could not be identified from the limited amount of evidence available at this time point. The lack of trials available was a limiting factor of this network meta-analysis, exemplified by the lack of studies reporting data on micronized dehydrated human amniotic/chorionic membrane beyond 2 months. Further trials are needed to provide a better estimate of the most effective injectable treatment for this condition at all time points.