The efficacy and safety of multiple doses of oral tranexamic acid on blood loss, inflammatory and fibrinolysis response following total knee arthroplasty: A randomized controlled trial

151 patients scheduled for a primary unilateral TKA for osteoarthritis or rheumatoid arthritis were randomized to receive a single 2g dose of oral TXA (2 hrs pre-operation), two doses of oral TXA (2 hrs pre-op, 4 hrs post-op) or multiple doses of oral TXA (2 hrs pre-op, 4, 10 16 hrs post-op). The primary outcome of interest was total blood loss. Results revealed significantly lower amounts of total blood loss in the multi-dose group compared to the single-dose and two-dose groups.