Ninety-five patients with carpometacarpal arthritis were randomized to receive autologous fat (n=25), platelet-rich plasma (PRP; n=24), autologous fat and PRP (n=25), or 0.9% saline solution (n=21). The primary outcome of interest was pain reduction. Secondary outcomes included improvements in hand function (QuickDASH score), quality of life (SF-36 score), range of motion, pinch, and power grip. Outcomes were assessed over a mean follow-up period of two years. Overall, the results revealed that the combination of autologous fat and PRP significantly reduced pain and improved both hand function and quality of life compared to saline. These findings suggest that combining autologous fat and PRP is a viable and safe alternative for managing pain and improving function in patients with CMC1 arthritis.