Seventy-eight patients with rotator cuff injuries were randomized to receive either mini-open rotator cuff repair combined with intraoperative cocktail therapy (n=39) or mini-open rotator cuff repair with saline injection (n=39). The primary outcome was postoperative pain measured by VAS scores. Secondary outcomes included postoperative use of analgesics (celecoxib and parecoxib sodium), Constant-Murley functional scores, passive abduction angles, and adverse events (nausea, infection). Outcomes were assessed at 6, 12, 24, and 48 hours postoperatively for pain, and at 2 weeks, 1, 3, and 6 months for functional measures. Overall, the results showed significantly lower VAS scores at early time points in the cocktail group, along with reduced use of postoperative analgesics. Additionally, the Constant-Murley functional scores and passive abduction angles were significantly higher in the cocktail group at 2 weeks and 1 month, but no differences were noted at 3 and 6 months. The findings suggest that intraoperative cocktail therapy effectively reduces early postoperative pain and accelerates functional recovery in the early postoperative period.