Eighty patients undergoing primary total hip arthroplasty were randomized to receive either tranexamic acid alone (n=40) or tranexamic acid combined with methylprednisolone (n=40). The primary outcomes were levels of CRP and IL-6 as markers of inflammation. Secondary outcomes included pain (VAS scores), use of analgesics, nausea and vomiting (PONV), blood glucose fluctuations, fatigue (ICFS), range of motion (ROM), blood loss, transfusion rates, postoperative hemoglobin and hematocrit, and complications. Outcomes were assessed up to 72 hours postoperatively. Overall, the study found that the combination of MP and TXA significantly reduced CRP and IL-6 levels, decreased pain and analgesic use, and improved postoperative fatigue and ROM, without increasing severe complications. These findings suggest that adding methylprednisolone to tranexamic acid can promote faster recovery and better early postoperative outcomes in THA patients.