Methylene Blue for the Treatment of Lumbar Facet Joint Syndrome .
Clinical Effects and Safety of the Use of Methylene Blue for the Treatment of Lumbar Facet Joint Syndrome.
Pain Physician. 2022 Jan;25(1): E15-E26.One hundred and twenty patients with lumbar facet joint syndrome due to osteoarthritis were randomized to receive an ultrasound-guided intra-articular injection of methylene blue (n=60) or diprospan (n=60). The primary outcome of interest was pain on a Numeric Rating Scale (NRS), measured up to 6 months post-operation. Secondary outcomes of interest included lumbar function, sleep quality, depression severity, treatment efficacy, post-operative analgesic consumption, and the incidence of complications. Results revealed significantly lower pain scores, better lumbar function and sleep quality, lower depression severity, and a lower incidence of hyperglycemia with methylene blue injection vs. control.
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