Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic Rotator Cuff Repair: A Randomized, Double-Blinded, Placebo-Controlled Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

This randomized, double-blinded, placebo-controlled trial enrolled 146 patients undergoing arthroscopic rotator cuff repair for full-thickness, nontraumatic small to large-sized rotator cuff tears. Patients were randomized 1:1 to receive either a placebo or 500 mg of metformin twice daily, for three months postoperatively. After loss to follow-up, 126 patients completed the study and were included in the final analysis (64 metformin, 62 control). The primary outcome was the incidence of postoperative shoulder stiffness at 3 months; secondary outcomes included American Shoulder and Elbow Surgeons (ASES) score, pain (VAS), patient satisfaction, plasma fibrotic biomarkers, and rotator cuff tendon healing assessed by ultrasonography. Outcomes were assessed at 3 months, 6 months, and 1 year postoperatively. Overall, the results of the study revealed a significantly lower incidence of shoulder stiffness in the metformin group compared with placebo at all postoperative time points, without adverse effects on tendon healing or clinically meaningful differences in long-term functional outcomes.