Efficacy of mesenchymal stem cells injection for the management of knee osteoarthritis: a systematic review and meta-analysis

この研究はハイインパクトの可能性があります。 OEのAI駆動型ハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文が持つ可能性の高い影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。

7 studies (6 RCTs and 1 CCT) that included a total of 314 patients with knee osteoarthritis (OA) were included in this meta-analysis and systematic review. The purpose of this review was to elucidate the efficacy of mesenchymal stem cell (MSC) injections in the treatment of knee OA by evaluating its effect on pain and function outcomes. While the findings of this study demonstrated potential efficacy for MSC injections for pain reduction and functional improvement that warrant further investigation, these findings were observed in a subgroup of higher quality studies or were associated with significant heterogeneity due to varying follow-up periods, doses of MSC and differing control groups. The low quality of evidence within the included trials limits the ability to draw conclusive results.