28 athletic patients with patellofemoral pain syndrome (PFPS) were randomized to receive active lumbopelvic manipulation or sham therapy for the purpose of determining if lumbopelvic manipulation therapy was associated with significantly improved electromyography (EMG) parameters, pain, and function when assessed immediately following the physiotherapy procedure. Results demonstrated significantly earlier onset and higher amplitude of EMG activity in the vastus medialis and gluteus medius muscle when compared to sham therapy. Furthermore, significantly improved pain and performance on the step-down test were observed in lumbopelvic manipulation patients when compared to sham therapy patients. Significant EMG parameter differences in the vastus lateralis, or significant differences in performance on the one-hop test were not detected when study groups were compared.