Fifty-eight patients with acute long bone fractures were randomized to receive either low-dose ketamine (LDK; n=31) or intravenous morphine (MOR; (n=27). The primary outcome of interest was the reduction in pain as measured by the Numerical Rating Scale (NRS) from baseline. Secondary outcomes included adverse effects and the need for rescue analgesia. Outcomes were assessed at 15, 30, 60, 90, and 120 minutes after treatment. Overall, the study revealed that LDK resulted in a greater reduction in NRS scores at 30 minutes compared to MOR and continued to show significant pain relief at 60 minutes. However, LDK was associated with a higher incidence of dizziness. These findings suggest that LDK can be a more effective short-term adjunct analgesic for acute long-bone fractures but with some tolerable side effects.