Low-dose radiation therapy ineffective versus sham for alleviating symptomatic hand osteoarthritis .
Lack of beneficial effects of low-dose radiation therapy on hand osteoarthritis symptoms and inflammation: a randomised, blinded, sham-controlled trial
Osteoarthritis Cartilage. 2018 Oct;26(10):1283-1290. doi: 10.1016/j.joca.2018.06.01056 patients with hand osteoarthritis were randomized to either low dose radiation therapy or sham intervention. Protocols were administered over 6 sessions for the duration of 2 weeks, with follow-up performed at 1, 2, and 3 months after treatment. The primary outcomes of OMERACT-OARSI response rate at 3 months demonstrated no significant difference between the LDRT group and the sham group. In addition, no significant differences were observed for changes in clinical scores of pain and function, or ultrasound parameters of effusion, synovial thickening, and Power Doppler signal intensity.
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