Lorazepam vs. Diazepam in the treatment of Pediatric Status Epilepticus .
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Lorazepam vs Diazepam for Pediatric Status Epilepticus A Randomized Clinical Trial
JAMA. 2014 Apr 23-30;311(16):1652-60Three hundred and ten patients, aged 3 months to 18 years, exhibiting tonic-clonic status epilepticus were randomized to determine a superior treatment between lorazepam and diazepam. Goals of treatment were cessation of status epilepticus by 10 minutes, without recurrence within 30 minutes. Patients were evaluated over 4 hours after treatment, and up to 24 hours, or until hospital discharge for safety and secondary outcome analysis. The evidence presented in this study indicated that lorazepam and diazepam were comparable in the treatment of status epilepticus in terms of all primary outcomes analyzed in this trial. Lorazepam patients were, however, more likely to be sedated compared to diazepam patients.
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