72 patients with proximal humeral fracture were randomized to undergo surgical treatment via fixation with either intramedullary nails or interlocking plates for the purpose of comparing clinical outcomes throughout a 12-month follow-up period. Outcomes of interest included shoulder pain, function, shoulder passive range of motion, radiographic analysis, requirement of re-operation, and incidence of complications. Results demonstrated that the majority of clinical outcomes of interest (including pain, function, range of motion, neck-shaft angle) were comparable between study groups at 3, 6 and 12 months. However, internal rotation at 6 months, number of complications, and number of reoperations were significantly higher in the nail group when compared to the plate group.