Leukocyte-Rich versus Leukocyte-Poor Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Trial
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2021;9(13):11 Am J Sports Med. 2022 Mar;50(3): 609-617.What this means for my practice?
The results of this trial found that 3 weekly leukocyte-rich and leukocyte-poor platelet-rich plasma injections provided similar clinical outcomes in patients with symptomatic knee osteoarthritis. This study was limited by the lack of imaging evaluation.
Study Summary
192 patients with unilateral, symptomatic knee osteoarthritis were randomized to receive 3 weekly intra-articular injections of leukocyte-rich platelet-rich plasma (n=96) or leukocyte-poor platelet-rich plasma (n=96). The primary outcome of interest was the International Knee Documentation Committee (IKDC) score at 12 months. Secondary outcomes of interest included the Knee Injury and Osteoarthritis Outcomes Score (KOOS) sub-scales, the Tegner scale for activity/sporting level, and Euro-QoL Visual Analog Scale (EQ-VAS) for quality of life. No significant differences in all outcomes were observed between the two groups, at 2, 6 and 12 months follow-up.
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