Late PONV reduced with ramosetron vs ondansetron following TKA under spinal anesthesia .
Comparison of Ramosetron With Ondansetron for Prevention of Intrathecal Morphine-Induced Nausea and Vomiting After Primary Total Knee Arthroplasty: A Randomized Control Trial
J Arthroplasty. 2017 Mar;32(3):1040-104390 patients scheduled for total knee arthroplasty under spinal anesthesia and intrathecal morphine were randomized to antiemesis with either ramosetron or ondansetron. Patients were assessed for the incidence of nausea and vomiting, and severity of nausea, over the first 48 hours postoperatively. Results demonstrated a significantly lower incidence of nausea in the ramosetron group compared to the ondansetron group at 6 hours and from 12-24 hours postoperatively. Additionally, the incidence of vomiting was significantly lower in the ramosetron group compared to the ondansetron group from 18-24 hours postoperatively.
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