Knee OA symptoms better improved with hyaluronic acid treatment vs. 6-methylprednisolone .
Hyaluronic Acid Versus Methylprednisolone Intra-Articularly Injected for the Treatment of Osteoarthritis of the Knee
Current Therapeutic Research. 1991 Nov;50(5):691-99
90 patients with knee osteoarthritis were included in this trial and randomized to receive either sodium hyaluronate (NaHA) or 6-methylprednisolone acetate (6-MPA) as treatment. The study was conducted in order to compare efficacy and tolerability of the two drugs in knee OA. While pain, joint flexion, and duration of morning stiffness outcomes significantly favoured HA treatment, analgesic consumption and tolerability were comparable among groups. Patient- and physician-judgement of efficacy also favoured HA treatment.
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