Knee OA: MRI assessments reveal early effect of chondroitin sulphate on cartilage loss .
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Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI
Ann Rheum Dis. 2011 Jun;70(6):982-9. doi: 10.1136/ard.2010.140848. Epub 2011 Mar 170 patients with primary knee osteoarthritis were randomized to receive either 800 mg chondroitin sulphate (CS) or a placebo once a day for 6 months to determine the effects of CS on joint cartilage, assessed using magnetic resonance imaging (MRI). Results revealed that 800 mg chondroitin sulphate had an early effect (6 months) on cartilage volume loss and on bone marrow lesions at 12 months. Additionally, patients in the CS group who were taking non-steroidal anti-inflammatory drugs (NSAIDs) had significantly less synovial membrane thickness than patients in the placebo group taking NSAIDs. There were no significant differences in pain, function, stiffness, use of rescue medications or adverse events between the two groups.
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