Thirty-two patients with carpal tunnel syndrome were randomized to receive either kinesio taping with active release technique (n=16) or kinesio taping alone (n=16). Outcomes of interest were pain on a Numeric Rating Scale (NRS), grip strength, Boston Carpal Tunnel Questionnaire (BCTQ), and range of motion. Outcomes were assessed at baseline and after 4 weeks. Overall, the results of the study revealed that the group receiving kinesio taping with the active release technique showed significantly greater improvements in pain, functional status, and range of motion compared to the kinesio taping alone group. The findings suggest that combining kinesio taping with the active release technique is more effective than kinesio taping alone for improving clinical outcomes in carpal tunnel syndrome.