Ketamine + Epidural Morphine for Postoperative Analgesia After Lumbar Laminectomy or Discectomy .
Adding Ketamine to Epidural Morphine Does Not Prolong Postoperative Analgesia After Lumbar Laminectomy or Discectomy.
J Neurosurg Anesthesiol . 2024 Jul 1;36(3):244-251.Forty-eight patients undergoing lumbar laminectomy or discectomy were randomized to receive either epidural morphine alone (n=24) or epidural morphine with ketamine (n=24). The primary outcome was the duration of analgesia, measured as the time to the first postoperative analgesic request. Secondary outcomes included pain scores at rest and movement, systemic hemodynamics, and the incidence of side effects within 24 hours postoperatively. Overall, the study found no significant difference in the duration of analgesia between the groups. The addition of ketamine did not provide prolonged analgesia or additional benefit. These findings suggest that ketamine does not enhance the efficacy of epidural morphine in this context.
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