IV magnesium sulphate does not increase CSF Mg levels in spinal anaesthesia patients .
This report has been verified
by one or more authors of the
original publication.
Changes in cerebrospinal fluid magnesium levels in patients undergoing spinal anaesthesia for hip arthroplasty: does intravenous infusion of magnesium sulphate make any difference? A prospective, randomized, controlled study
Br J Anaesth. 2012 Aug;109(2):208-15. doi: 10.1093/bja/aes146. Epub 2012 Jun 145 neurologically healthy patients undergoing continuous spinal anaesthesia for hip arthroplasty were randomized to receive intravenous magnesium sulphate (MgSO4) or saline. Over 6 hours, the magnesium concentration in the serum increased in the MgSO4 group and decreased in the saline group. However, both groups demonstrated a decrease in the cerebrospinal fluid (CSF) magnesium concentration at 2 hours. This concentration returned to baseline by 6 hours. There was no difference between the two groups at any time period for the concentration of CSF magnesium or for any other ion concentration in the CSF.
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