ISASS: Use of rhBMP-2 and autologous bone in PLIF display similar clinical outcomes .
The Effect of rhBMP-2 in one-level PLIF
40 patients undergoing posterior lumbar interbody fusion (PLIF) were randomized to receive polyetheretherketone (PEEK) cages filled with either recombinant human bone morphogenic protein (rhBMP-2) or autologous bone to compare their clinical and radiological effects. At 24 months, the incidence of end plate resorption, osteolysis, and ectopic bone formation were frequently observed with rhBMP-2; however, this did not result in any clinical differences when compared with autologous bone.
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