Pain Relief After Total Knee Arthroplasty with Intravenous and Periarticular Corticosteroid: A Randomized Controlled Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

180 patients scheduled to undergo a total knee arthroplasty were randomized to receive corticosteroid applied intravenously (n=45), peri-articularly (n=45), or both (n=45), or a placebo treatment (n=45). The primary outcome of interest was post-operative pain as measured on a Numeric Rating Scale (NRS). Functional outcomes, mobility scores, morphine consumption, quality of recovery and discharge destination were also assessed, up to 3 days post-operation. Between the 3 corticosteroid groups, no differences were observed in all outcomes in all between-group comparisons. However, patients who received the combination treatment or the intravenous treatment reported significantly more improvements over placebo, particularly with respect to pain, morphine consumption, muscle power, walking distance, and quality of recovery. The combination group showed further benefits over placebo in knee flexion, mobility scores, and home discharge rate, suggesting that a combination of peri-articular and intravenous corticosteroid may facilitate the quickest recovery vs. other administration strategies after total knee arthroplasty.