Intraosseous administration of low-dose vanomycin leads to higher tissue concentrations .
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original publication.
Higher tissue concentrations of vancomycin with low-dose intraosseous regional versus systemic prophylaxis in TKA: a randomized trial
Clin Orthop Relat Res. 2014 Jan;472(1):57-65. doi: 10.1007/s11999-013-3038-z32 patients scheduled for total knee arthroplasty were randomized to received three different prophylactic antibiotic regimens: intraosseous administration of either 250mg or 500mg vanomycin, or 1g vanomycin administered intravenously. The purpose was to evaluate the effect of intraosseously administered vanomycin in terms of concentrations in subcutaneous fat, cancellous bone, and systemic blood samples. Intraoperative concentrations of vanomycin in tissue samples were significantly higher with either dose of intraosseous vanomycin compared to intravenous administration.
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