Intranasal ketamine an effective alternative to IV morphine for acute analgesia in EDs .
This report has been verified
by one or more authors of the
original publication.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2017;5(8):14 BMC Emerg Med. 2016 Nov 9;16(1):4390 patients presenting to the emergency department with moderate to severe pain due to mild or moderate blunt trauma were randomized to be managed with either intranasal (IN) ketamine, intravenous (IV) morphine, or intramuscular (IM) morphine. Patients were assessed for pain every 5 minutes for the first 60 minutes after administration. Results demonstrated significantly earlier onset of clinically relevant pain reduction in the IN ketamine and IV morphine groups compared to the IM morphine group. Adverse events related to confusion, dizziness, and difficulty concentrating were more frequent following IN ketamine administration, while morphine administration was associated with a greater incidence of dry mouth.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
Ja = 1
Ungewiss = 0.5
Nicht relevant = 0
Nein = 0
Die Bewertung der Berichtskriterien bewertet die Transparenz, mit der die Autoren die methodischen und studienspezifischen Merkmale der Studie in der Veröffentlichung angeben. Die Bewertung ist in fünf Kategorien unterteilt, die im Folgenden vorgestellt werden.
1/4
Randomization
2/4
Outcome Measurements
2/4
Inclusion / Exclusion
4/4
Therapy Description
4/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
Der Fragilitätsindex ist ein Instrument, das bei der Interpretation signifikanter Ergebnisse hilft und ein Maß für die Stärke eines Ergebnisses liefert. Der Fragilitätsindex gibt die Anzahl der aufeinanderfolgenden Ereignisse an, die zu einem dichotomen Ergebnis hinzugefügt werden müssen, damit das Ergebnis nicht mehr signifikant ist. Eine kleine Zahl steht für ein schwächeres Ergebnis und eine große Zahl für ein stärkeres Ergebnis.
Warum wurde diese Studie jetzt benötigt?
Patients presenting to the orthopaedic emergency department are often in a significant amount of pain. Opiates have traditionally been used as a form of analgesia in these patients. The use of these drugs often requires close monitoring of patients, as hemodynamic or respiratory complications can be quite common. Interest has increased in the possible use of intranasal ketamine in the treatment of these patients, avoiding not only the need for the monitoring associated with opioids, but also avoiding the administration of injections. There is a paucity of evidence evaluating the use of intranasal ketamine in this setting; hence, the need for this study.
Was war die wichtigste Forschungsfrage?
In the management of pain for patients presenting to the ED with traumatic limb or spine injuries, what is the efficacy and safety of intranasal ketamine, compared to either intravenous morphine or intramuscular morphine, when assessed over the first 60 minutes after admittance?
- Time to clinically relevant pain reduction was significantly shorter in the IN ketamine group (14.3min [95%CI 9.8-18.8]) and the IV morphine group (8.9min [95%CI 6.6-11.2]) compared to the IM morphine group (26.0min [95%CI 20.3-31.7]) (p=0.003 and 0.000, respectively); there was no significant difference between the IN ketamine group and the IV morphine group (p=0.300).
- Overall maximum VAS pain reduction within the first 60 minutes did not significantly differ between the IN ketamine group (56mm), IV morphine group (59mm), and the IM morphine group (48mm) (p=0.300).
- No significant differences in the percentage of patients who did not demonstrate a clinically relevant pain reduction were observed between groups.
- Adverse event monitoring demonstrated a significantly higher incidence of difficulty concentrating in the IN ketamine group compared to the two morphine groups. The was also a significantly higher incidence of confusion in the IN ketamine group compared to the IV morphine group, and a significantly higher incidence of dizziness in the IN ketamine group compared to the IM morphine group. Adverse events related to dry mouth were significantly more frequent in the morphine groups compared to the IN ketamine group.
- Overall, no significant difference in the degree of patient satisfaction was observed between the IN ketamine group (58.7mm [95%CI 45.3-72.1]), IV morphine group (70.2mm [95%CI 55.2-85.2]), and IM morphine group (73.9mm [95%CI 62.9-84.9]).
- No statistically significant differences in vital signs were observed between the three groups.
Was sollte ich mir besonders merken?
In the management of pain for those presenting to emergency departments with traumatic limb or spine injuries, the use of intranasal ketamine demonstrated similar analgesic efficacy and hemodynamic/respiratory safety over 60 minutes after administration when compared to intravenous morphine. Both intranasal ketamine and intravenous morphine demonstrated significantly more rapid onset of analgesia when compared to intramuscular morphine.
Wie wird sich dies auf die Behandlung meiner Patienten auswirken?
The results of this study suggest that intranasal administration of ketamine may offer an effective alternative and easier-to-administer method of acute analgesia to intravenous morphine in managing patients in emergency departments with severe pain due to blunt trauma resulting in limb and spine injuries.
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