Intra-articular mesenchymal stem cells possibly beneficial for meniscus regeneration .
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Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study
J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.0005860 patients undergoing a partial meniscectomy were randomized to receive a single postoperative injection of allogeneic human mesenchymal stem cells (50x10^6 or 150x10^6 cell count) or a control vehicle injection of sodium hyaluronate, 7-10 days after surgery. The purpose of this study was to determine if a single intra-articular injection of mesenchymal stem cells caused meniscal regeneration over 2 years, as well as to investigate the safety of such treatment. More patients treated with the stem cell injection were observed to have an increase in meniscus volume of >15%, and patients with osteorthritis appeared to have an added benefit of reduced pain. No significant immunological responses were observed.
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