One hundred elderly patients scheduled for upper extremity fracture surgery were randomized to receive either intravenous-inhalation anesthesia or intravenous-inhalation anesthesia with interscalene brachial plexus block (IBPB). This study aimed to investigate whether the use of IBPB with intravenous-inhalation anesthesia would be more effective than isolated intravenous-inhalation anesthesia. Intraoperative complications were documented, vital signs were assessed over 120 minutes after anaesthesia was induced, and postoperative recovery and side effects were assessed over 4-6 weeks. The results of this study indicated that the group which received the combination anesthetic needed less recovery time, suffered lower intraoperative side effects, had lower consumption of propofol and isoflurane posteropatively and no postoperative side effects. Vital signs had negligible difference between groups.