Influences of route of acetaminophen administration and periarticular liposomal bupivacaine in TKA .
Effectiveness of Novel Adjuncts in Pain Management Following Total Knee Arthroplasty: A Randomized Clinical Trial
J Arthroplasty. 2018 Jul;33(7S):S136-S141. doi: 10.1016/j.arth.2018.02.088211 patients scheduled for total knee arthroplasty were randomized to one of three multimodal analgesia regimens: oral acetaminophen and periarticular infiltration with a standard knee injection cocktail, oral acetaminophen and periarticular infiltration with liposomal bupivacaine, and intravenous acetaminophen and periarticular infiltration with a standard knee injection cocktail. Primary outcomes included pain scores, narcotic consumption, and opioid-related adverse events. Results demonstrated no significant differences in pain scores and opioid-related side-effects between the three groups, while total narcotic consumption within the first 24 hours was significantly greater in the group administered liposomal bupivacaine compared to the other two groups.
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