Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression .
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Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression
Neuropharmacology. 2018 11-Apr;():. 10.1016/j.neuropharm.2017.12.041An open label case series comparing pre- to post-psilocybin administration in 20 patients with moderate to severe treatment resistant depression on fMRI responses to emotional faces was undertaken. Participants were shown fearful, happy or neutral facial expressions while in an fMRI machine before and after receiving 25 mg of oral psilocybin, and the blood oxygen level dependent (BOLD) signals were contrasted between pre and post drug administration. After psilocybin use increased responses to fearful and happy faces were seen in the right amygdala, with increases in right amygdala to fearful faces versus neutral faces predictive of clinical improvements in depression at 1 week.
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