Improvement of condition with hyaluronic acid injection for ankle OA .
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Effectiveness of intra-articular hyaluronic acid for ankle osteoarthritis treatment: a systematic review and meta-analysis
Arch Phys Med Rehabil. 2013 May;94(5):951-60. doi: 10.1016/j.apmr.2012.10.030. Epub 2012 Nov 10Four randomized controlled trials, 1 double-arm comparative study, and 4 single-arm prospective studies were included in this investigation into the efficacy of hyaluronic acid (HA) injections for ankle osteoarthritis. A total of 354 patients were included throughout the studies. Pooled effect sizes indicated a significantly beneficial effect of HA compared to pre-treatment condition. Comparative analysis of HA against reference treatment tended to favour HA injection, although statistical significance was not exhibited. Furthermore, comparison to saline suggested that a placebo effect may be present with HA injections.
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